I upgraded to Vista 64-bit about 2 months ago now. For the most part, no major problems. I was hoping that it would show all 4GB of memory I've got, but it turns out that it isn't an "addressable space" issue but a "crappy old chipset" issue. Apparently the Santa Rosa intel chipsets don't have this problem or some other daft hardware thing (I'm a software guy...damn hardware :) )
Anyway, Office 2007 is a 32-bit app and 32-bit apps run fine using a thing in vista called Windows on Windows (or WoW). However, there is some functionality that you don't get:
The ones in bold are the really painful ones for me. I put faxes in the same basket as telex and telegrams. In addition, there are a couple of other things that don't quite work on Vista 64 bit:
Obviously, none of these are deal breakers - but given that I want to be able to demonstrate all the cool features of Office 2007 running on bare metal rather than virtualised, I think it is time to re-image. Now, about those backups...
I would also like to have office in 64 bit os.