The purpose of this post is to highlight the most common current title issues and, where possible, supply work-arounds. For general troubleshooting see the previous post first: the most common problems are described there. Items will be listed in reverse chronological order (ie newer titles will be at the top). If you have any issue be sure you are running the latest version of the player software which is 2.0.5127 right now. I hope to update this post as new information becomes available. Note that this list is culled from issues we have seen here in-house and have debugged. General rumors and fantastical claims will not be featured in this list.
 
[Various] Matrix Discs ("Can't read disc")
 
If you have this error with these discs (and other HD DVDs work fine), and have updated the player software to the latest version without improving the situation, please contant the manufacturer for a replacement disc.
 
Star Trek Original Series 1 (US version) (hang on Disc 6, during "Galileo 7" credits)
Bourne Ultimatum (hang in Chapter 15)
 
Press FF then Play to get it "unstuck" 
 
Harry Potter Order of the Phoenix (hang during IME playback)
 
Fixed in 2.0.4645
 
Heroes, Evan Almighty, Transformers (hang after saving a bookmark)
 
Workaround is to not be connected to the network. Fixed in 2.0.4645.

Hot Fuzz (error C667000A after Universal logo)

Sporadic issue, retry and it should work fine. Fixed in 2.0.4641

Children of Men, The Good Shepherd ("Can't read disc")

A batch of these discs had a manufacturing defect, please contact Universal for a replacement disc. See http://hddvd.highdefdigest.com/news/show/603

Relentless Enemies ("Can't read disc")

This disc is not compatible with every Xbox 360 HD DVD drive. There is no work-around at this time.