Enclosed is an example of a Biztalk Error that can be resolved by the application of an Microsoft .NET Framework 2.0 hotfix.
Enterprise Single Sign-On
Server1 "An error occurred while attempting to access the SSO database.Function: GetGlobalInfoFile: infocache.cpp:1349System.Data : Timeout expired. The timeout period elapsed prior to obtaining a connection from the pool. This may have occurred because all pooled connections were in use and max pool size was reached..SQL Error code: 0xE2E2E2E2Error code: 0xC0002A21, An error occurred while attempting to access the SSO database.