I saw this problem reported on a Windows 2000 Server (IIS 5.0), I've not checked if the same could also happen on IIS 6/7...
The application is build on classic ASP pages and the error appeared about once per day on a test server; when browsing the user got a message reading "unable to create new session" (rough translation from Italian), and when this happens the only solution was to reset IIS (while in that status, even static HTML content was not served).
Interestingly the Event Log showed quite a few entries like the following:
Event Type: Warning Event Source: COM+ Event Category: Activation Event ID: 4238 Date: 03/07/2007 Time: 11.05.49 User: N/A Computer: xxxxxxxx Description: COM+ has determined that your machine is running very low on available memory. In order to ensure proper system behavior, the activation of the component has been refused. If this problem continues, either install more memory or increase the size of your paging file. Memory statistics are: dwMemoryLoad = 98 dwTotalPhys = 536358912 dwAvailPhys = 9453568 dwTotalPageFile = 1945448448 dwAvailPageFile = 48668672 dwTotalVirtual = 2147352576 dwAvailVirtual = 405975040 Server Application ID: {3D14228D-FBE1-11D0-995D-00C04FD919C1} Server Application Name: IIS Out-Of-Process Pooled Applications
Event Type: Warning Event Source: COM+ Event Category: Activation Event ID: 4238 Date: 03/07/2007 Time: 11.05.49 User: N/A Computer: xxxxxxxx
Description: COM+ has determined that your machine is running very low on available memory. In order to ensure proper system behavior, the activation of the component has been refused. If this problem continues, either install more memory or increase the size of your paging file. Memory statistics are: dwMemoryLoad = 98 dwTotalPhys = 536358912 dwAvailPhys = 9453568 dwTotalPageFile = 1945448448 dwAvailPageFile = 48668672 dwTotalVirtual = 2147352576 dwAvailVirtual = 405975040
Server Application ID: {3D14228D-FBE1-11D0-995D-00C04FD919C1} Server Application Name: IIS Out-Of-Process Pooled Applications
This turned out to be due to a memory pressure problem in inetinfo.exe: a hang dump showed a problem with the ASP Template Cache which was using most of the memory (this usually happens when you have a lot of lines of code in one single ASP page, or your application heavily include files); here are some suggestions to mitigate the issue:
By the way, point number 1 above resolved the problem for the customer.
Even if not directly related to this problem, we disabled ScriptScan from McAfee, which is not supported server-side:
http://knowledge.mcafee.com/SupportSite/search.do?cmd=displayKC&docType=kc&externalId=KB40067&sliceId=SAL_Public&dialogID=1503790&stateId=0%200%201505251 "When installed to a server, McAfee recommends that ScriptScan be disabled. Jscript and VBScript protection is intended for use with Microsoft Internet Explorer and Microsoft Outlook, which generally are not used on server platforms. Additionally, ScriptScan is not designed for high-throughput requirements of servers"
http://knowledge.mcafee.com/SupportSite/search.do?cmd=displayKC&docType=kc&externalId=KB40067&sliceId=SAL_Public&dialogID=1503790&stateId=0%200%201505251
"When installed to a server, McAfee recommends that ScriptScan be disabled. Jscript and VBScript protection is intended for use with Microsoft Internet Explorer and Microsoft Outlook, which generally are not used on server platforms. Additionally, ScriptScan is not designed for high-throughput requirements of servers"
Carlo