I was experimenting with the SharePoint 2010 User Profile Service.  I had a simple console application and used the code found in the UserProfileManager documentation as a starting point.  But any time I tried to create a new UserProfileManager object I got an UserProfileApplicationNotAvailableException.

I made sure I followed all of the steps in Configure profile synchronization but I still was getting the exception.

Steve Peschka finally pointed me to his post on "No User Profile Application Available" Mystery in SharePoint 2010' and that solved it.