podfeed.net is an up-and-coming directory listing for podcasts. There are some great podcasts on podfeed including "This Week in Tech" (Leo Laporte and other ex-TechTV stars) or the Engadget podcast. If you're not a techie, you can find lots of other podcasts organized by categories like Politics, Hobbies, Religion, Music, News, Comedy, or even "mature content". You can also add your own podcast or create a customized list of your podcasts feeds.
And thanks to Steve Jobs, iTunes will be supporting podcasts in the future. Excellent :)