If you're having trouble with CLRProfiler crashing the aspnet_wp process, along the lines of this forum post:

http://forums.microsoft.com/MSDN/ShowPost.aspx?PostID=1039428&SiteID=1

then you'll want to know that we have officially uploaded a fixed version of CLR Profiler here: 

http://www.microsoft.com/downloads/details.aspx?FamilyID=a362781c-3870-43be-8926-862b40aa0cd0&DisplayLang=en

So please feel free to go there directly to get the latest and greatest.  (The update is for CLR 2.x only).