We have come across this specific issue on Windows 2003 (post service pack 1) and Windows XP (post service pack 2) where the machine experiences slow performance and we observe many DCOM 10010 ERRORS in the event logs. If you are running in to this issue...

We have a few articles that describe how to enable large file transfers with WSE 3.0(see references section below). The main thing to note here is that WSE by default buffers the attachments before they are sent, so when the file size is large(typically...