If you're a SourceSafe on Vista type of person, here's some current information from Richard Berg to be aware of --

Part 1:
http://blogs.msdn.com/richardb/archive/2007/01/23/clarifying-sourcesafe-support-on-vista.aspx

Part 2:
http://blogs.msdn.com/richardb/archive/2007/01/26/sourcesafe-on-vista-part-2.aspx