I have previously posted on High Performance Computing and what it may mean to ISVs. Currently two of my ISVs are getting very active with the beta of Windows HPC Server 2008 in the area of Financial Services which is exciting - but not nearly as exciting (IMVHO) as using HPC to address the needs of ISVs building video games to deliver a render/compute farm :-) Check out this short video from on10.net which looks at the use of Windows Computer Cluster Server 2003 by Seven Group to deliver render farms for all those fantastic visuals.