North Carolina

TRINUG - Triangle .NET User Group (Raleigh)
The Triangle .NET User Group in Raleigh-Durham, NC meets the second Wednesday of each month.

Triad Developers Guild
The Triad Developers Guild, serving Greensboro, High Point and Winston-Salem, meets on the first Tuesday of each month.

Triad SQL Server User Group
The Triad SQL Server User Group meets the first Wednesday of each month at New Horizons Greensboro.

Charlotte Enterprise Developers Guild
The Charlotte Enterprise Developer's Guild meets the fourth Tuesday of each month (except December)

Charlotte SQL Server User Group

Western North Carolina
The Western North Carolina Developers Guild meets on the 2nd Tuesday of every month from 6 to 8:30 PM at ImageSmith Communications, near Asheville NC

South Carolina

Greenville Spartanburg Enterprise Developers Guild
The Greenville Spartanburg Enterprise Developers Guild meets the third Tuesday of each month.

Columbia Enterprise Developers Guild
Meets the second Wednesday of each month

GC.NET – Charleston, SC
GC.NET meets the second Thursday of each month.

PDANUG
The Pee Dee Area .NET User Group meeting the second Tuesday of each month in Florence, SC

Georgia

A handy calendar for upcoming Atlanta user groups is being thoughtfully maintained by the Atlanta .NET Regular Guys.

Atlanta Microsoft Professionals
Meets the first Monday of each month. Incorporates the Atlanta VB Study Group, Atlanta Mobility Group and Atlanta Cutting Edge

Atlanta SQL Server Group (AtlantaMDF)
Meets third Monday of each month.

Atlanta .NET User Group
Meets last Monday of each month. No meetings in May (Memorial Day) and December (New Years Eve).

Gwinnett Georgia Microsoft User Group
Meet second Thursday of each month

Augusta Developers Guild

Macon Dot Net