In short, a lot of what you do in the SSP admin console is executed through OWSTimer jobs. There is a known issue on 64 bit systems that can result in an exception being thown and the service will shutdown. From there what can happen is that whatever the job or jobs that are being executed may not finish and introduce an inconsistent state. For example, changing the password for service accounts causes access denied or 403 errors.
If you apply the following hotfix it should prevent future problems. You should definitly apply this Windows fix before applying Service Pack 1 or making any changes to the SSP. If you do not do this you place your SSP at risk.
http://support.microsoft.com/kb/946517 - Fix to correct 6482 Timer job Heap Corruption Issue on 64 bit system