For those who may not have seen this yet, there was an issue discovered in some of the SharePoint 2010 October Cumulative Update packages. This issue causes actions that use the user profile service to fail. Here is a brief description of the issue from the SharePoint team’s blog:

“The October Cumulative Update for the packages listed above (SharePoint Server Package 2394320 and Project Server Package 2394322) makes some changes and updates to the user profile database.  Unfortunately there are certain situations where this update does not complete as expected and leaves the update in an inconsistent state.  This causes issues with several SharePoint features that use the User Profile Application such as MySites, People and Expertise Search & Ratings.”

There is currently a workaround published on the Product Teams blog as well as more notes about the issue. If you have not installed the October CU for SharePoint 2010 yet, do not install it at this time. The updates have been pulled from the update servers and new versions will be published that do not cause the issue.

For those who have already installed the October CU, check the SharePoint teams blog for the current workaround:

SharePoint 2010 October Cumulative Update Issue: Details and Workaround (From the SharePoint Product team blog)