I've been running Vista on my work desktop PC for several weeks now. I've got to admit that I'm enjoying it. Will your PC be able to run Vista? Check out the new Vista Upgrade Advisor that will evaluate your PC for you.
If you've been ignoring all the talk around Vista since it was called Longhorn, then you should check out all the new features that the Vista team is bringing your way.
Vista and Office 2007 look pretty slick together, for sure!