If you are running XP / Windows 2000 / Windows 2003 - you MUST apply the update on http://www.microsoft.com/technet/security/Bulletin/MS05-051.mspx to stay protected against a critical vulnerability - after you install the Microsoft Security Bulletin MS05-051 - any of the following problems may occur (as per the above mentioned bulletin - Systems that have been modified to non default Access Control List settings on the %windir%\registration directory may experience unexpected behavior)
Please take a look at the following KB for a resolution to these problems - http://support.microsoft.com/?kbid=909444