After some discussions with the team they confirmed, that this will work with RTM, but there are a couple of limitations we should be aware of:
In the end I am very excited about the option of hosting WPF through IFRAME in a gadget because it's much easier creating a gadget that communicates with more complex web services in a much easier way than it is possible through the (in my opinion "limited") JavaScript APIs.
What does it mean? Well, everybody has the option! Create richer, WPF based pages for integrating with complex back-end applications and with other client applications like Outlook (as calling into Outlook or other client apps is much easier from a .NET based application than from JavaScript) or creating the nice, little, fancy JavaScript / DHTML based Sidebar gadgets...