Error:

When you specify domain level BizTalk Server Administrators Group and BizTalk Operators Group during BizTalk Server 2006 configuration, you get the following error:

Windows cannot process the object with the name "BizTalk Server Administrators" because of the following error:
The handle is invalid

or

Windows cannot process the object with the name "BizTalk Server Operators" because of the following error:
The handle is invalid

Cause:

You log on to the Windows using a local user account.

Solution:

log on to the Windows using a domain user account, and this account must be in the domain BizTalk Server Administrators group and the local administrators group of the local computer.