Phil in the team have been recording a pretty extensive set of 5 min Video about developing for certain segments of Windows Server 2008 R2.
Areas include Powershell V2, lots of Windows Server 2008 R2 Core development areas such as NUMA support and finally how to develop applications for Server Core. The best place to get started is to go to the main Windows Server 2008 R2 tag and drill down from there.
Here are the session titles
PowerShell V2 Modules
PowerShell V2 Sessions and Debugging
PowerShell V2 Functions
How To Debug ASP.NET Applications on Server Core
How to Deploy ASP.NET Applications on Server Core
How to Debug Native-Code Server Core Applications
How to Debug .NET Server Core Applications
How To Develop .NET Application in Windows Server 2008 R2, Server Core
How To Develop C++ Applications for Windows 2008 R2, Server Core
Mark Russinovich: Inside Windows 7
New NUMA Support with Windows & Windows Server 2008 R2, PM Talk
New NUMA Support with Windows Server 2008 R2 and Windows 7, Demo3
New NUMA Support with Windows Server 2008 R2 and Windows 7, Demo2
New NUMA Support with Windows Server 2008 R2 and Windows 7, Demo1
New NUMA Support with Windows Server 2008 R2 and Windows 7
Windows 7: Designing Efficient Background Processes
Windows 7: Web Services in Native Code
Developing Applications for Motion Sensors in Windows Server 2008 R2
Developing with Microsoft .NET and ASP.NET for Server Core