A little while ago, I did an interview with Brian Keller and the Channel 9 team to explain some of the Manual Testing experiences that were brought to light in the September CTP of Visual Studio 2010. If you haven't had a chance to see video, I would recommend looking it over.  In it you'll see that we have created a new UI, Camano, optimized for the generalist tester. 

James Whittaker, around the same time, did a channel 9 interview as well. In it he explains some of the steps that we are taking to make software testers first class citizens in VS2010.