Wow I read this today in Parade Magazine then went online to watch the lecture.  Carnegie Mellon Computer Science Professor Randy Pausch gave a talk that is truly his last lecture.  You see he's dying of cancer.  His simple but amazingly impactful words are worth a read or listen to.  Take the time - you can't help but be impressed by this incredible man who gives us the lessons he hopes to leave behind. 

http://www.parade.com/articles/editions/2008/edition_04-06-2008/1My_Last_Lecture