Not exactly mainstream fiction, or even mainstream scifi, but it’s based on an Xbox game published by MSGS.
Mass Effect: Ascension
The central character (not the protagonist) is described as having autism and several parts of the book are from her perspective. I thought it was interesting and a generally positive treatment of a character on the spectrum.
Not sure how Drew came to the character or whether she will put in an appearance in the Mass Effect sequel, but I sent him an email to ask.
Drew's personal website
It was a pretty good book, but in the interest of full disclosure, since Mass Effect is my all-time favorite single-player game, bar none, I would’ve read the book any way.
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