So obviously you would never do the following in a "real" environment unless you were sure of the ramifications, but I was recently building InfoPath (SP1) forms to use with a SharePoint and BizTalk demo when I got the following error trying to either preview the InfoPath form, or, open it from the SharePoint site:

"Infopath cannot open the selected form. The form or its associated form template are from a restricted security zone and may be unsafe."

I played around with a few things, and stumbled upon this KB article that shows you how to quickly tell InfoPath to apply domain-level security.

Given that it is often said that InfoPath is to BizTalk what Outlook is to Exchange, it's good for us to know how to wrangle this beast and show it who's boss from time to time.