Giving a presentation? Want to focus just on the editor (and any interesting tools windows) without modifying your basic (design) view of Visual Studio? Press Shift+Alt+Enter (or View – Full Screen) to enter full screen mode.
Whatever happens in Full Screen Mode stays in Full Screen Mode. Besides being a bad pun on the Las Vegas ads, whatever modifications you make in Full Screen Mode will not affect the design mode or any other mode.
There are four window layout modes in Visual Studio: Design, Debugging / Running, Full Screen, and single file. The single file is when you run devenv <filename> from the command line. Making a customization in on of these will persist only in that mode and not affect any other.