Saurab, a PM on the UiFX team posted a screencast on the new application services coming in Visual Studio Orcas enabling settings to be cached locally, and synchronized with the profile store in ASP.net.  He also demonstrates caching authentication and roles as well.

http://blogs.msdn.com/saurabh/archive/2006/11/27/live-from-redmond-client-application-services-in-orcas.aspx

The screencast is a bit old, and seems sluggish, so for those that prefer a walkthrough, Saurab and Karl have created this step by step info:

http://blogs.msdn.com/winformsue/archive/2007/05/20/client-application-services-in-windows-forms-end-to-end-walkthrough-available.aspx

 

Steve