On the Microsoft podcasts site you can find a recently released podcast, Forefront Online Protection for Exchange and Office 365 - Better Together (direct link to the mp3), that addresses how Forefront Online Protection for Exchange and Office 365 can work together. It focuses mainly on features of FOPE and how the FOPE service can be tailored to work in a stand-alone environment (where you don't have any cloud mailboxes) and in a cross-premises environment (where some of your mailboxes are hosted by on-premises Exchange and a portion are hosted by Exchange Online).

The intended audience is an IT professional or manager who works on enterprise messaging and messaging security.