Check out this excellent article:
http://windowsclient.net/wpfdesigner/articles/first-wpf-application.aspx

The article walks you through creating a basic WPF application.

You will learn to easily create, move and align controls, create data bindings and edit control collections using the powerful features of the WPF Designer for Visual Studio 2010.

Oh, and by the way, there is also a video that shows this http://windowsclient.net/learn/video.aspx?v=171694