In Walkthrough: Adding Controls to a Worksheet at Run Time in an Application-Level Project, you can see  to add host controls at run time in an application-level add-in by using Visual Studio 2008 SP1.  This video is posted to the How Do I Videos - Visual Basic page, part of the Visual Basic Developer Center.

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How Do I: Add Controls to a Worksheet at Run Time in an Application-Level Project?

Mary Lee, Programming Writer.