ASP.NET AJAX 4.0
Great MIX09 talk on ASP.NET AJAX 4.0. Stephen Walther is a really great presenter.
I’m not an AJAX expert, but the improvements in ver 4 are pretty clear. The big news is vastly improved client-side support. Wrapping your server-side controls with update panels is no longer necessary, as there is a much richer set of client-side controls, templates, etc.
In addition, you can do some pretty rich stuff declaritively—that is, without writing JavaScript. This stuff is too complicated for me to explain, but Piyush Shah has a great blog post on much of the new AJAX 4.0 functionality.