Paul Stubbs blogs about how easy we made deployment in VSTO Orcas. http://blogs.msdn.com/pstubbs/archive/2007/05/17/vsto-my-favorite-feature-clickonce-deployment.aspx We got rid of our dependency on caspol and now have a version independent policy store.
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Check out a screen cast on channel 9 that shows how VSTO Orcas will enable you to easily create solutions that mix existing VBA code with new VSTO code. http://channel9.msdn.com/ShowPost.aspx?PostID=306413#306413
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