Please have a look at the two webcasts covering running DotNetNuke on ASP.NET 2.0

http://msevents.microsoft.com/cui/WebCastEventDetails.aspx?EventID=1032275044&EventCategory=5&culture=en-US&CountryCode=US Part 1
http://msevents.microsoft.com/cui/WebCastEventDetails.aspx?EventID=1032275051&EventCategory=5&culture=en-US&CountryCode=US Part 2

For more information on DotNetNuke please see http://dotnetnuke.com