The following edge case applies to MOSS 2007 (and not WSS 3.0).  When using the following pattern the property Microsoft.Office.Server.UserProfiles.PersonalSite requires a Dispose() call before leaving scope if you use the property in your code.  Below is an example of a common usage of PersonalSite property.

void PersonalSiteLeak()
{
    // open a site collection
    using (SPSite siteCollection = new SPSite("http://moss"))
    {
        UserProfileManager profileManager = new UserProfileManager(ServerContext.GetContext(siteCollection));
        UserProfile profile = profileManager.GetUserProfile("domain\\username");
        SPSite personalSite = profile.PersonalSite;    // will leak
    }
}

void PersonalSiteNoLeak()
{
    // open a site collection
    using (SPSite siteCollection = new SPSite("http://moss"))
    {
        UserProfileManager profileManager = new UserProfileManager(ServerContext.GetContext(siteCollection));
        UserProfile profile = profileManager.GetUserProfile("domain\\username");
        using (SPSite personalSite = profile.PersonalSite)
        {
            // ...
        }
    }
}

From a web context performance perspective it is more efficient to get your UserProfile object in the following example:

UserProfile myProfile = ProfileLoader.GetProfileLoader().GetUserProfile();
using (SPSite personalSite = myProfile.PersonalSite)
{
     // ...
}

Note the use of ProfileLoader to get the shared UserProfile instance for my own profile.  There is no need to open a fresh SPSite in the case where you’re browsing a page.  Additionally, if your web part is designed to be placed on a My Site, there is even a shared PersonalSite instance that will be disposed for you and does not require you to call Dispose() with this technique:

IPersonalPage currentMySitePage = this.Page as IPersonalPage;
if (currentMySitePage != null && !currentMySitePage.IsProfileError)
{
     SPSite personalSite = currentMySitePage.PersonalSite; // will not leak
     // ...
}

Thanks to Microsoft’s Anant Dimiri and Bryant Fong for their contributions!