Here are few things you need to know when you want to setup and configure BizTalk Server Disaster Recovery Scenario.

Pre-requisite: Please ensure that all BizTalk Databases are backed up regularly

Checklist: Increasing Availability with Disaster Recovery: http://msdn.microsoft.com/en-us/library/cc296886(BTS.10).aspx

Best Practices for Disaster Recovery: http://msdn.microsoft.com/en-us/library/cc296756(BTS.10).aspx

BizTalk Server SQL Server Log Shipping: http://msdn.microsoft.com/en-us/library/cc296856(BTS.10).aspx

How to Restore Your Databases: http://msdn.microsoft.com/en-us/library/dd759730(BTS.10).aspx

High Availability for Databases: http://technet.microsoft.com/en-us/library/cc296692(BTS.10).aspx 

For the operations team, the critical thing is to run the VBscript files to update the databases and the registry on the BizTalk Servers. The Scripts can be found in the BizTalk Server Install folder Under Schema and Restore.

·         On 64-bit computers, you must run UpdateDatabase.vbs/ UpdateRegistry.vbs from a 64-bit command prompt.

·         You only need to run UpdateDatabase.vbs on one server in the BizTalk group.

·         You need to run UpdateRegistry.vbs on every server in the BizTalk group.