After setting up a SSL enabled site collection using SSL, with ISA running with a single rule, you are not able to browse to the SSL enabled site collection. The cause for this is simple: each SSL enabled site collection must have it’s own rule
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I've had a couple of customer come across this issue, which is actually a limitation that is put in place out of box. By default, the web.config file is set to allow only 50 items to be displayed on the navigation menu chrome on the top of any portal.
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