In VS 2005, VSD does not support Seamless "Mixed mode" debugging a.k.a interop debugging. However this is being actively considered for future releases of VS and .NET CF.

However if you need to debug a solution that includes both Managed and Native Code check out the following walkthroughs.

http://msdn2.microsoft.com/en-us/library/ms228818.aspx

http://blogs.msdn.com/davidklinems/archive/2005/06/02/424595.aspx

Stay tuned!

Srinivas N