One of my absolute favourite shortcuts in Internet Explorer that I use probably 50 times a day and VistaClues reminded me to blog about it.

If you want to go to a .com website and you know it's something like www.nike.com for example, just type nike in the address bar and hit Ctrl + Enter. Bingo!

[update] John reminded me that you can do this with just "Enter" in Firefox. One less keystroke for the RSI conscious!

Link to Open a Website Without Typing .Com - Windows Vista help